Alternatives to Layla

One of the widest formularies in the ranking — both molecules, an oral route, and brand access, all nationwide.

Sema

$244/mo

Tirz

$325/mo

Coverage

All 50 states

A LegitScript-certified, physician-supervised program with a rare oral GLP-1 tablet alongside injectables — both molecules, transparent no-insurance pricing, and a brand-name path.

Sema

$193/mo

Tirz

$242/mo

Coverage

All 50 states

The best all-around match: nationwide access, both molecules at one flat, no-surprise price, and an easy exit.

Sema

$99/mo at every dose

Tirz

$149/mo at every dose

Coverage

All 50 states

He & She MD is a nationwide telehealth weight-loss clinic offering doctor-prescribed GLP-1 medications: compounded semaglutide and tirzepatide (injectable or oral), with brand-name…

Sema

$199/mo (monthly plan)

Tirz

$159/mo

Coverage

All states except Louisiana (GLP-1)

Weight-loss treatment from $199/mo across all 50 states plus Puerto Rico, spanning compounded injectables, oral tablets and brand-name Ozempic — but the price you actually pay appears only after intake.

Sema

$199/mo

Tirz

$299/mo

Coverage

All 50 states

A coaching-first program that now spans compounded injectables, an oral orforglipron option and brand-name Wegovy — priced low only if you prepay a year.

Sema

$289/mo month-to-month cash

Tirz

$289/mo month-to-month cash

Coverage

All 50 states

Semaglutide Online is a LegitScript-certified telehealth platform prescribing compounded and brand-name GLP-1/GIP medications nationwide (excluding Alabama).

Sema

$222/mo

Tirz

$354/mo

Coverage

All 50 states

The one brand-name-only option here: you pick a named clinician at a posted price, and the medication is billed separately at cash-pay rates.

Sema

$149/mo brand Wegovy pill

Tirz

$299/mo brand Zepbound vial

Coverage

Not disclosed