MatchScript · Guides · Updated August 2026
The complete GLP-1 guide library.
Everything we know about getting weight-loss medication right — choosing a provider, what it costs, which molecule fits, and how to use it safely. Every guide is sourced to primary research or official labeling.
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All 528 ranked →We may earn a commission if you start care through some of these links, at no extra cost to you. What we write about a provider is the same either way, providers we have a commercial relationship with are listed first on most boards, and every Match Score is computed from the six published factor sub-scores regardless. See our disclosure.
- 191CoreAge RxVisit
- $99/mo at every dose
- All 50 states
- A− match
- 284Strut HealthVisit
- $131/mo
- Oral option
- B match
FDA issued Strut Health, LLC dba Strut a warning letter in February 2026. See FDA's warning-letter database.
- 383EdenVisit
- $198/mo
- All 50 states
- B match
FDA issued Eden Health International Inc. dba Eden a warning letter in June 2026. See FDA's warning-letter database.
- 485RoVisit
- Not disclosed
- All 50 states
- B match
- 582Telos RxVisit
- $99/mo injectable
- All 50 states
- B− match
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37 guides
- How to Choose a GLP-1 Provider That Fits YouA friendly checklist for picking a GLP-1 telehealth provider — budget, formulary, speed, support and coverage — plus how our quiz matches you.Choosing a provider
- Best GLP-1 Provider by Need: Budget, Oral, Fast Start, or NationwideThe best GLP-1 provider depends on your need. Our picks for budget, oral options, fast starts, and nationwide access — matched to what you want.Choosing a provider
- Best GLP-1 Provider for Long-Term Use: What Maintenance Evidence SaysGLP-1s work as long as you stay on them. Here's what the maintenance trials show, and how to pick a provider you won't outgrow in year two.Choosing a provider
- How Much Does Semaglutide Cost Without Insurance? (2026 Telehealth Pricing)Brand Wegovy cash price vs. compounded telehealth pricing, what's included, plan-length discounts, and HSA/FSA — real 2026 semaglutide pricing.Cost & coverage
- How Much Does Tirzepatide Cost Without Insurance? (2026 Telehealth Pricing)Brand Zepbound self-pay price vs. compounded tirzepatide telehealth pricing, what's included, and HSA/FSA — real 2026 tirzepatide costs without insurance.Cost & coverage
- Does Insurance Cover GLP-1 Weight-Loss Drugs? (2026 Coverage Reality)The real state of GLP-1 coverage in 2026: commercial plans, Medicare's weight-loss exclusion, Medicaid, prior authorization, and why so many people pay cash.Cost & coverage
- Semaglutide vs. Tirzepatide: Head-to-Head on Weight Loss, Side Effects, and CostMechanism, the pivotal STEP and SURMOUNT trials, the head-to-head data, tolerability, and real telehealth pricing — an honest semaglutide vs tirzepatide guide.Compare the medications
- Injections vs Oral or Sublingual GLP-1: Which to PickInjectable GLP-1s have the big trials behind them; oral and sublingual options trade some evidence for convenience. A measured guide to picking your format.Compare the medications
- Compounded vs. Brand-Name GLP-1s: What the Evidence Actually ShowsFDA approval status, the 503A/503B pharmacy split, the shortage resolution, safety, and cost — an honest, sourced look at compounded vs brand GLP-1s.Compare the medications
- Is Compounded GLP-1 Legit and Safe?A measured look at compounded GLP-1: what 503A and 503B pharmacies are, how LegitScript and the FDA fit in, and how to vet a provider.Compare the medications
- GLP-1 Dosing & Titration Schedule: Semaglutide and Tirzepatide Step-Up ChartsThe standard semaglutide (Wegovy) and tirzepatide (Zepbound) titration schedules, why the slow step-up matters, maintenance doses, and missed-dose guidance.Using the medication
- GLP-1 Side Effects and How to Manage Them (Nausea, GI, and Red Flags)What semaglutide and tirzepatide side effects feel like, when they hit, how to blunt nausea and GI upset, and the red-flag symptoms that need a clinician.Using the medication
- Do GLP-1s Cause Muscle Loss? What the Evidence Says (and How to Protect Lean Mass)GLP-1 weight loss includes some lean mass — here's what the trial data actually shows, why it happens, and how protein and resistance training protect muscle.Using the medication
- What Happens When You Stop Taking a GLP-1? (Weight Regain & How to Come Off)The evidence on weight regain after stopping semaglutide or tirzepatide, why it happens, and how to taper and build a maintenance plan that holds.Using the medication
- Tirzepatide Dosage Chart: Every Step From 2.5 mg to 15 mgThe labeled schedule, week by week: 2.5 mg for four weeks, then 2.5 mg increments no sooner than every four weeks, to a 15 mg maximum.More guides
- GLP-1 Units to mg: Why 20 Units Is Not One AnswerUnits measure volume, not drug. The same 20 units is a different dose from every vial — here is the arithmetic and why no fixed chart can be right.More guides
- "GLP-1 Face": Why Rapid Weight Loss Changes Your Face, and What HelpsWhat dermatology research actually shows about "Ozempic face" — the facial volume loss from rapid weight loss — why it happens, and what helps.More guides
- GLP-1 Injection Guide: Sites, Technique, and Pen Instructions by BrandWhere to inject Ozempic, Wegovy, Mounjaro, or Zepbound, how to rotate sites, and pen technique — straight from each drug's current FDA label.More guides
- Does GLP-1 Medication Cause Hair Loss? What the Evidence ShowsOzempic, Wegovy, Mounjaro, and Zepbound are all linked to hair shedding — here's what the dermatology research actually says, and when it grows back.More guides
- Ozempic vs. Wegovy, Mounjaro vs. Zepbound: Same Drug, Different BrandOzempic and Wegovy are the same molecule; so are Mounjaro and Zepbound. Here's exactly what differs — indication, dose, and why it matters for you.More guides
- GLP-1 Medication and Alcohol: Drinking, Cravings, and What the Research ShowsCan you drink on a GLP-1? What the trial evidence actually shows about alcohol tolerance, cravings, and why researchers are now testing these drugs for AUD.More guides
- GLP-1 Weight-Loss Plateau: Why It Happens and What Actually HelpsWhy weight loss on semaglutide or tirzepatide slows or stalls — the physiology behind a plateau, what the trial data shows, and what actually helps.More guides
- GLP-1s vs. Older Weight-Loss Pills: Phentermine, Contrave, and Qsymia ComparedHow semaglutide and tirzepatide actually compare to phentermine, phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), and orlistat.More guides
- GLP-1 and Sleep Apnea: What the Zepbound OSA Trial FoundZepbound is FDA-approved to treat obstructive sleep apnea. Here's what the SURMOUNT-OSA trial actually found, and what it means for treatment and coverage.More guides
- GLP-1s and Heart Health: What the SELECT Trial Means for YouWegovy is FDA-approved to reduce cardiovascular risk, not just body weight. Here's what the landmark SELECT trial found and why it matters for coverage.More guides
- GLP-1 Medication and Pregnancy, Breastfeeding, and Birth ControlWhat the Wegovy and Zepbound labels actually say about pregnancy timing, breastfeeding, and a real interaction with oral birth control — sourced, not guessed.More guides
- GLP-1 Medication for PCOS: What the Evidence ShowsPCOS isn't an FDA-approved GLP-1 indication, but real trial evidence supports its use for weight loss and hormonal regulation. Here's what's actually proven.More guides
- How to Store GLP-1 Medication: Fridge, Room Temperature and When to Throw It OutHow long semaglutide and tirzepatide last in the fridge, how long they can be out of it, and when to discard — the exact windows from each drug's own label.More guides
- How Long Does Semaglutide Take to Work? The Three Timelines That Get ConfusedWhen semaglutide reaches full strength, when appetite changes, and when the scale moves — three different timelines, from the label and the trials.More guides
- Switching From Semaglutide to Tirzepatide: What Actually HappensWhether you can switch GLP-1s, why your dose does not carry across, what the head-to-head trial found, and the questions worth asking before you move.More guides
- The Edit Review: Who Should Sign Up, Who Shouldn'tThe Edit charges $209/mo for semaglutide and $309 for tirzepatide. Every prepay figure divides correctly, and the $109 headline is a first-order promo.More guides
- Pepti Review: $99 Semaglutide, One Unresolved FlagPepti prices injectable semaglutide at $99/mo flat at every dose. A per-dose ladder buried in its own data says otherwise, and we could not break the tie.More guides
- Trellis Vitality Review: $150 Sema, One GapTrellis publishes a real 1/3/6-month GLP-1 table starting at $150 month-to-month — and a single 'starting at' figure for everything else. Both matter.More guides
- Auren Rx Review: File the Monthly Rung, Not $129Auren Rx prices every SKU twice — a subscribe rung and a no-commitment rung. Its own nav, selector and JSON-LD all point at the cheaper one. Ours doesn't.More guides
- Vyvron Review: 13 Charges a Year, Not 12Vyvron prints '/mo' and bills every four weeks, and its tirzepatide plans are not monthly at all — the cheapest one is $790 up front. What that costs you.More guides
- Rehydra+ Review: 6 Months, Non-CancelableEvery Rehydra+ GLP-1 membership is a six-month non-cancelable contract, so the $119/mo headline is really $714. Here is what you can actually buy monthly.More guides
- Lighter You Review: A Price You Cannot CheckLighter You advertises 'start for just $99'. No program costs $99, the cheapest is $145, and the only route to a real price is behind a login. Details below.More guides
Choosing a provider
How to pick a telehealth GLP-1 program you can trust — and stick with.
How to Choose a GLP-1 Provider That Fits You
A friendly checklist for picking a GLP-1 telehealth provider — budget, formulary, speed, support and coverage — plus how our quiz matches you.
Read the guideBest GLP-1 Provider by Need: Budget, Oral, Fast Start, or Nationwide
The best GLP-1 provider depends on your need. Our picks for budget, oral options, fast starts, and nationwide access — matched to what you want.
Read the guideBest GLP-1 Provider for Long-Term Use: What Maintenance Evidence Says
GLP-1s work as long as you stay on them. Here's what the maintenance trials show, and how to pick a provider you won't outgrow in year two.
Read the guide
Cost & coverage
What GLP-1s really cost without insurance, and whether your plan will pay.
How Much Does Semaglutide Cost Without Insurance? (2026 Telehealth Pricing)
Brand Wegovy cash price vs. compounded telehealth pricing, what's included, plan-length discounts, and HSA/FSA — real 2026 semaglutide pricing.
Read the guideHow Much Does Tirzepatide Cost Without Insurance? (2026 Telehealth Pricing)
Brand Zepbound self-pay price vs. compounded tirzepatide telehealth pricing, what's included, and HSA/FSA — real 2026 tirzepatide costs without insurance.
Read the guideDoes Insurance Cover GLP-1 Weight-Loss Drugs? (2026 Coverage Reality)
The real state of GLP-1 coverage in 2026: commercial plans, Medicare's weight-loss exclusion, Medicaid, prior authorization, and why so many people pay cash.
Read the guide
Compare the medications
Semaglutide vs. tirzepatide, injections vs. oral, and compounded vs. brand.
Semaglutide vs. Tirzepatide: Head-to-Head on Weight Loss, Side Effects, and Cost
Mechanism, the pivotal STEP and SURMOUNT trials, the head-to-head data, tolerability, and real telehealth pricing — an honest semaglutide vs tirzepatide guide.
Read the guideInjections vs Oral or Sublingual GLP-1: Which to Pick
Injectable GLP-1s have the big trials behind them; oral and sublingual options trade some evidence for convenience. A measured guide to picking your format.
Read the guideCompounded vs. Brand-Name GLP-1s: What the Evidence Actually Shows
FDA approval status, the 503A/503B pharmacy split, the shortage resolution, safety, and cost — an honest, sourced look at compounded vs brand GLP-1s.
Read the guideIs Compounded GLP-1 Legit and Safe?
A measured look at compounded GLP-1: what 503A and 503B pharmacies are, how LegitScript and the FDA fit in, and how to vet a provider.
Read the guide
Using the medication
Dosing, side effects, protecting muscle, and what happens when you stop.
GLP-1 Dosing & Titration Schedule: Semaglutide and Tirzepatide Step-Up Charts
The standard semaglutide (Wegovy) and tirzepatide (Zepbound) titration schedules, why the slow step-up matters, maintenance doses, and missed-dose guidance.
Read the guideGLP-1 Side Effects and How to Manage Them (Nausea, GI, and Red Flags)
What semaglutide and tirzepatide side effects feel like, when they hit, how to blunt nausea and GI upset, and the red-flag symptoms that need a clinician.
Read the guideDo GLP-1s Cause Muscle Loss? What the Evidence Says (and How to Protect Lean Mass)
GLP-1 weight loss includes some lean mass — here's what the trial data actually shows, why it happens, and how protein and resistance training protect muscle.
Read the guideWhat Happens When You Stop Taking a GLP-1? (Weight Regain & How to Come Off)
The evidence on weight regain after stopping semaglutide or tirzepatide, why it happens, and how to taper and build a maintenance plan that holds.
Read the guide
More guides
Additional evidence-based reading from the MatchScript library.
Tirzepatide Dosage Chart: Every Step From 2.5 mg to 15 mg
The labeled schedule, week by week: 2.5 mg for four weeks, then 2.5 mg increments no sooner than every four weeks, to a 15 mg maximum.
Read the guideGLP-1 Units to mg: Why 20 Units Is Not One Answer
Units measure volume, not drug. The same 20 units is a different dose from every vial — here is the arithmetic and why no fixed chart can be right.
Read the guide"GLP-1 Face": Why Rapid Weight Loss Changes Your Face, and What Helps
What dermatology research actually shows about "Ozempic face" — the facial volume loss from rapid weight loss — why it happens, and what helps.
Read the guideGLP-1 Injection Guide: Sites, Technique, and Pen Instructions by Brand
Where to inject Ozempic, Wegovy, Mounjaro, or Zepbound, how to rotate sites, and pen technique — straight from each drug's current FDA label.
Read the guideDoes GLP-1 Medication Cause Hair Loss? What the Evidence Shows
Ozempic, Wegovy, Mounjaro, and Zepbound are all linked to hair shedding — here's what the dermatology research actually says, and when it grows back.
Read the guideOzempic vs. Wegovy, Mounjaro vs. Zepbound: Same Drug, Different Brand
Ozempic and Wegovy are the same molecule; so are Mounjaro and Zepbound. Here's exactly what differs — indication, dose, and why it matters for you.
Read the guideGLP-1 Medication and Alcohol: Drinking, Cravings, and What the Research Shows
Can you drink on a GLP-1? What the trial evidence actually shows about alcohol tolerance, cravings, and why researchers are now testing these drugs for AUD.
Read the guideGLP-1 Weight-Loss Plateau: Why It Happens and What Actually Helps
Why weight loss on semaglutide or tirzepatide slows or stalls — the physiology behind a plateau, what the trial data shows, and what actually helps.
Read the guideGLP-1s vs. Older Weight-Loss Pills: Phentermine, Contrave, and Qsymia Compared
How semaglutide and tirzepatide actually compare to phentermine, phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), and orlistat.
Read the guideGLP-1 and Sleep Apnea: What the Zepbound OSA Trial Found
Zepbound is FDA-approved to treat obstructive sleep apnea. Here's what the SURMOUNT-OSA trial actually found, and what it means for treatment and coverage.
Read the guideGLP-1s and Heart Health: What the SELECT Trial Means for You
Wegovy is FDA-approved to reduce cardiovascular risk, not just body weight. Here's what the landmark SELECT trial found and why it matters for coverage.
Read the guideGLP-1 Medication and Pregnancy, Breastfeeding, and Birth Control
What the Wegovy and Zepbound labels actually say about pregnancy timing, breastfeeding, and a real interaction with oral birth control — sourced, not guessed.
Read the guideGLP-1 Medication for PCOS: What the Evidence Shows
PCOS isn't an FDA-approved GLP-1 indication, but real trial evidence supports its use for weight loss and hormonal regulation. Here's what's actually proven.
Read the guideHow to Store GLP-1 Medication: Fridge, Room Temperature and When to Throw It Out
How long semaglutide and tirzepatide last in the fridge, how long they can be out of it, and when to discard — the exact windows from each drug's own label.
Read the guideHow Long Does Semaglutide Take to Work? The Three Timelines That Get Confused
When semaglutide reaches full strength, when appetite changes, and when the scale moves — three different timelines, from the label and the trials.
Read the guideSwitching From Semaglutide to Tirzepatide: What Actually Happens
Whether you can switch GLP-1s, why your dose does not carry across, what the head-to-head trial found, and the questions worth asking before you move.
Read the guideThe Edit Review: Who Should Sign Up, Who Shouldn't
The Edit charges $209/mo for semaglutide and $309 for tirzepatide. Every prepay figure divides correctly, and the $109 headline is a first-order promo.
Read the guidePepti Review: $99 Semaglutide, One Unresolved Flag
Pepti prices injectable semaglutide at $99/mo flat at every dose. A per-dose ladder buried in its own data says otherwise, and we could not break the tie.
Read the guideTrellis Vitality Review: $150 Sema, One Gap
Trellis publishes a real 1/3/6-month GLP-1 table starting at $150 month-to-month — and a single 'starting at' figure for everything else. Both matter.
Read the guideAuren Rx Review: File the Monthly Rung, Not $129
Auren Rx prices every SKU twice — a subscribe rung and a no-commitment rung. Its own nav, selector and JSON-LD all point at the cheaper one. Ours doesn't.
Read the guideVyvron Review: 13 Charges a Year, Not 12
Vyvron prints '/mo' and bills every four weeks, and its tirzepatide plans are not monthly at all — the cheapest one is $790 up front. What that costs you.
Read the guideRehydra+ Review: 6 Months, Non-Cancelable
Every Rehydra+ GLP-1 membership is a six-month non-cancelable contract, so the $119/mo headline is really $714. Here is what you can actually buy monthly.
Read the guideLighter You Review: A Price You Cannot Check
Lighter You advertises 'start for just $99'. No program costs $99, the cheapest is $145, and the only route to a real price is behind a login. Details below.
Read the guide
Ready to find your match?
Read the guides, then let the quiz weigh budget, molecule, and support into an honest Match Score and surface the providers that fit you.