Signos review
Signos (Signos+) is a metabolic-health platform that bundles clinician-prescribed compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor (CGM) and app — pairing the medication with…
- Scores never bought
- 537 providers tracked
- Every factor auditable
- Updated August 2026
Semaglutide here is $271/mo — $72 above our category median of $199.
- Semaglutide
- $271/mo
- Tirzepatide
- $334/mo
- Coverage
- Coverage not published
- Brand-name
- Compounded only
- Oral option
- Injectable only
- Verification
- Not independently listed
Best for: People who want pairing compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor and app.
MatchScript's take: Our #395 pick of 537 — a focused, straightforward program.
The factor breakdown
Signos on the six Match Score factors — the same sub-scores the quiz reweights to your priorities. See the methodology.
Semaglutide from $271/mo puts Budget Fit at a below-par 43 — above the budget tiers.
Limited or undisclosed state coverage can slow your start, for a below-par 62 on Speed to Start.
Signos sticks to compounded injectables, for a below-par 66 on Formulary Match.
Support lands at a solid 82 — solid, standard support.
Flexibility scores a below-par 20 — fewer levers to flex your plan.
Thinner public disclosure than the top of the ranking keeps Transparency at a below-par 72.
Pricing in context
How Signos's monthly price sits against the category median and the cheapest provider we track.
What we like
- Bundles compounded GLP-1 (semaglutide) with an FDA-cleared CGM and app — glucose-guided weight loss, not just medication
- Starting at $199/mo on a 6-month program, with the CGM included at no extra cost
- Free rapid shipping; HSA/FSA eligible
- Real-time glucose insights and app coaching to help sustain results after GLP-1
The caveats
- Compounded GLP-1s are not FDA-approved finished products
- Headline price is a 6-month-program rate, not month-to-month
- Only semaglutide is shown in the program; tirzepatide availability is not confirmed
- Compounding pharmacy partner and state availability are not published on the landing page
Who it's for — and who should skip it
Signos is for people who want pairing compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor and app.
Skip it if that doesn't sound like you. A closer fit may be Lttl (Match Score 58) — or take the quiz to see where Signos lands for your priorities.
How it compares to CoreAge Rx & the closest scorer
Signos against our #1 overall pick and the provider that scores closest to it. Green marks the row leader.
| How it compares | Signosthis provider | CoreAge Rxour #1 | FormBlendsclosest scorer |
|---|---|---|---|
| Sema price | $271/mo | $99/mo at every dose | $179/mo |
| Coverage | Coverage not published | All 50 states | Coverage not published |
| Formulary | Injectable | Injectable | Injectable + brand |
| Match Score | 57 · C | 91 · A− | 57 · C |
Signos, answered
Is Signos legit?
Signos is a real, operating GLP-1 telehealth program. LegitScript certification is the third-party check worth asking for — look for the seal on their site and confirm your prescriber is US-licensed at intake. Like most programs here it dispenses compounded GLP-1s, which are made by a licensed pharmacy but aren't FDA-approved.
How much does Signos cost?
Signos lists compounded semaglutide from $271/mo and tirzepatide from $334/mo — above our category median of $199/mo. These are the provider's public figures at our last review (August 2026); confirm on their site, since some teaser tiers step up after month one.
Does Signos ship to my state?
Signos doesn't publish a full state list, so confirm your state is covered during intake before you pay.
Signos vs Lttl — which should I pick?
They score within a few points of each other: Signos at 57/100 and Lttl at 58/100, so neither wins on the headline number. Signos is the better fit for people who want pairing compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor and app. Lttl suits shoppers who want every commitment tier priced openly, plus a low-dose microdose option. Run the quiz and the weighting shifts to whichever of those matters more to you.
Pricing & state data last verified August 2026 from Signos's public site and our master provider matrix. The Match Score and its sub-scores are our editorial judgment per the methodology. Commercial facts only — prices change, so confirm on Signos's site. Not medical advice; see our disclosure.
Semaglutide here is $271/mo — $72 above our category median of $199. Tirzepatide is $334/mo. It scores highest on the care that comes after the first vial. Best suited to people who want pairing compounded GLP-1 (semaglutide) with an FDA-cleared continuous glucose monitor and app. If that is not you, Lttl is the closest thing to it here.
Compare with other providers
Our next-best picks in default ranking order, then the 24 programs that sit nearest Signos here.
- #1Match91/ 100CoreAge RxThe best all-around match: nationwide access, both molecules at one flat, no-surprise price, and an easy exit.91/100
- #2Match84/ 100Strut HealthThe only program here carrying both LegitScript and ACHC accreditation, with an oral lozenge route on both molecules at the cheapest entry in this ranking.84/100
- #3Match83/ 100EdenA polished, high-disclosure compounded program with strong nationwide coverage and hands-on support.83/100
- #4Match85/ 100RoA heavyweight telehealth brand with brand-name access and a polished experience — but opaque compounded pricing.85/100
- #5Match85/ 100No BS RXThe highest Transparency score here, and it is not close: twenty-four prices on one public page and four dispensing pharmacies named with street addresses.85/100
Compare 24 nearby providersHide them
| Provider | Tirzepatide price | Coverage | Alternatives | Go | ||
|---|---|---|---|---|---|---|
| TeleSlim Clinic#396 | 57 | $248/mo | Not disclosed | 6 states | Alternatives | Visit |
| EOS Health#397 | 57 | $202/mo | $303/mo | 40 states | Alternatives | Visit |
| LevelUp Rx#398 | 57 | $152/mo | $254/mo | Coverage not published | Alternatives | Visit |
| Remi Meds#399 | 57 | $249/mo (0.25 mg dose, compounded) | $349/mo (2.25 mg dose, compounded) | Coverage not published | Alternatives | Visit |
| Brello Health#400 | 57 | $158/mo | $197/mo | 35 states | Alternatives | Visit |
| T2D.com#401 | 57 | $185/mo | $999/mo (starting dose, compounded) | 1 state | Alternatives | Visit |
| Medical Health Institute#402 | 57 | $100/mo | Not disclosed | Coverage not published | Alternatives | Visit |
| ShapeIn Rx#403 | 56 | $208/mo | Not disclosed | Coverage not published | Alternatives | Visit |
| Form Health#404 | 56 | $1,350/mo (starting dose, brand-name) | $1,350/mo (starting dose, brand-name) | All 50 states | Alternatives | Visit |
| LVNG RX#405 | 56 | $151/mo | $253/mo | Coverage not published | Alternatives | Visit |
| MDLive#406 | 56 | Not disclosed | Not disclosed | Coverage not published | Alternatives | Visit |
| Medivive#407 | 56 | Not disclosed | Not disclosed | Coverage not published | Alternatives | Visit |
| Metabolyz#408 | 56 | Not disclosed | Not disclosed | All 50 states | Alternatives | Visit |
| QuickMD#409 | 56 | $279/mo (compounded) | Not disclosed | Coverage not published | Alternatives | Visit |
| SkyRx#410 | 56 | $199/mo (all doses, 12-month plan, compounded) | Not disclosed | Coverage not published | Alternatives | Visit |
| Strive Pharmacy#411 | 56 | Not disclosed | Not disclosed | All 50 states | Alternatives | Visit |
| Vital Edge#412 | 56 | $350/mo (compounded) | $450/mo (compounded) | Coverage not published | Alternatives | Visit |
| Vyora Wellness#413 | 56 | $299/mo (compounded) | $445/mo | Coverage not published | Alternatives | Visit |
| Dollar Dad Club#414 | 56 | $199/mo | Not disclosed | Coverage not published | Alternatives | Visit |
| Whoosh Wellness#415 | 56 | $169/mo | $249/mo | Coverage not published | Alternatives | Visit |
| HumeCare+#416 | 53 | $283/mo | $385/mo | Coverage not published | Alternatives | Visit |
| Aquivia Health#417 | 55 | $271/mo | $369/mo | Coverage not published | Alternatives | Visit |
| MANÜ Telehealth#418 | 55 | $202/mo | $301/mo | Coverage not published | Alternatives | Visit |
| Eve#419 | 55 | $273/mo | $406/mo | Coverage not published | Alternatives | Visit |
Signos is ranked on our best semaglutide providers, best tirzepatide providers and best GLP-1 programs boards, scored on the same six factors as every other provider there.