1st Optimal review
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets.
- Scores never bought
- 497 providers tracked
- Every factor auditable
- Updated July 2026
1st Optimal earns a Match Score of 45/100 (grade C) and sits #489 of 497 on our board under the balanced default weighting.
- Semaglutide
- Not disclosed
- Tirzepatide
- Not disclosed
- Coverage
- Coverage not published
- Brand-name
- Compounded only
- Oral option
- Yes
- Verification
- Not independently listed
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
MatchScript's take: Our #489 pick of 497 — one of the few with a non-injection route, scored on the same six factors as everyone else.
The factor breakdown
1st Optimal on the six Match Score factors — the same sub-scores the quiz reweights to your priorities. See the methodology.
Its lowest tier isn't clearly disclosed puts Budget Fit at a below-par 48 — above the budget tiers.
Limited or undisclosed state coverage can slow your start, for a below-par 33 on Speed to Start.
1st Optimal adds an oral/sublingual route on top of injectables, for a below-par 51 on Formulary Match.
Support lands at a solid 82 — solid, standard support.
Flexibility scores a below-par 37 — fewer levers to flex your plan.
Disclosure here is thinner than the top of the board give a below-par 20 on Transparency.
Pricing in context
How 1st Optimal's monthly price sits against the category median and the cheapest provider we track.
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
The caveats
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Who it's for — and who should skip it
Choose 1st Optimal if patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Skip it if that doesn't sound like you. A closer fit may be Blue Haven RX (Match Score 46) — or take the quiz to see where 1st Optimal lands for your priorities.
How it compares to CoreAge Rx & the closest scorer
1st Optimal against our #1 overall pick and the provider that scores closest to it. Green marks the row leader.
| How it compares | 1st Optimalthis provider | CoreAge Rxour #1 | Blue Haven RXclosest scorer |
|---|---|---|---|
| Sema price | Not disclosed | $149/mo | Not disclosed |
| Coverage | Coverage not published | All 50 states | Coverage not published |
| Formulary | Injectable + oral | Injectable | Injectable |
| Match Score | 45 · C | 91 · A− | 46 · C |
1st Optimal, answered
Is 1st Optimal legit?
1st Optimal is a real, operating GLP-1 telehealth program, but we don't find it on the LegitScript registry, so it carries less third-party verification than the certified providers on our board. It dispenses compounded medication, which isn't FDA-approved. Vet the prescriber and pharmacy before you commit.
How much does 1st Optimal cost?
1st Optimal doesn't publish a clear compounded-semaglutide price up front. You'll typically see full pricing after the intake questionnaire. Get the all-in monthly number in writing before you pay.
Does 1st Optimal ship to my state?
1st Optimal operates in a limited set of states (Coverage not published). If yours isn't on that list, you'll need a nationwide provider instead.
1st Optimal vs CoreAge Rx — which is better?
Both are on our board. 1st Optimal scores 45/100; CoreAge Rx leads our default ranking at 91/100 for its flat nationwide pricing on both molecules and easy cancellation. 1st Optimal can still win for you if its strengths match your priorities — best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. Run the quiz to see which comes out ahead for you.
Pricing & state data last verified July 2026 from 1st Optimal's public site and our master provider matrix. The Match Score and its sub-scores are our editorial judgment per the methodology. Commercial facts only — prices change, so confirm on 1st Optimal's site. Not medical advice; see our disclosure.
1st Optimal earns a Match Score of 45/100 (grade C) and sits #489 of 497 on our board under the balanced default weighting. 1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. If it isn't the right fit, Blue Haven RX is a sensible alternative to weigh next.
Compare with other providers
Our next-best picks in default ranking order, then the 19 programs that sit nearest 1st Optimal on the board.
- #1Match91/ 100CoreAge RxThe best all-around match: nationwide access, both molecules at one flat, no-surprise price, and an easy exit.91/100
- #2Match88/ 100Strut HealthThe only program here carrying both LegitScript and ACHC accreditation, with an oral lozenge route on both molecules at the cheapest entry on this board.88/100
- #3Match86/ 100HealthRXA LegitScript-certified, physician-supervised program with a rare oral GLP-1 tablet alongside injectables — both molecules, transparent no-insurance pricing, and a brand-name path.86/100
- #4Match86/ 100ShedRxA weight-focused program that also offers an oral/sublingual route for the needle-averse.86/100
- #5Match88/ 100Ondra HealthNear rock-bottom pricing on both molecules plus some brand access — a rare budget-and-breadth combo, nationwide.88/100
Compare 19 nearby providersHide them
| Provider | Tirzepatide price | Coverage | Alternatives | Go | ||
|---|---|---|---|---|---|---|
| Enhance MD#6 | 85 | $212/mo | $280/mo | 39 states | Alternatives | Visit |
| Eden#7 | 87 | $239/mo | $349/mo | All 50 states | Alternatives | Visit |
| Vaylen#8 | 87 | $179/mo | $239/mo | All 50 states | Alternatives | Visit |
| Found#9 | 84 | $289/mo month-to-month cash | $289/mo month-to-month cash | All 50 states | Alternatives | Visit |
| yourEra#10 | 84 | $199/mo | $299/mo | All 50 states | Alternatives | Visit |
| Telos Rx#11 | 84 | $49/mo | $99/mo | All 50 states | Alternatives | Visit |
| Trimi#12 | 84 | $129/mo | $229/mo | All 50 states | Alternatives | Visit |
| Sprout Health#13 | 84 | $149/mo starting | $199/mo starting | 44 states — list not disclosed | Alternatives | Visit |
| Alan Meds#14 | 86 | $99/mo | $145/mo | All 50 states | Alternatives | Visit |
| Curex#15 | 86 | $199/mo | $199/mo | All 50 states | Alternatives | Visit |
| Effecty#16 | 86 | $160/mo | $240/mo | All 50 states | Alternatives | Visit |
| JM Integrated Health#490 | 44 | Not disclosed | Not disclosed | 6 states | Alternatives | Visit |
| California Trim Clinic#491 | 43 | Not disclosed | Not disclosed | Coverage not published | Alternatives | Visit |
| Modern Age#492 | 43 | Not disclosed | Not disclosed | Coverage not published | Alternatives | Visit |
| This Gen Wellness#493 | 43 | Not disclosed | Not disclosed | 1 states | Alternatives | Visit |
| TRT Kingdom#494 | 43 | Not disclosed | Not disclosed | Coverage not published | Alternatives | Visit |
| AM Rx#495 | 42 | $151/mo (quarterly plan, plus a separate fee, compounded) | Not disclosed | Coverage not published | Alternatives | Visit |
| Bodyshop Wellness#496 | 40 | Not disclosed | Not disclosed | Coverage not published | Alternatives | Visit |
| OlleveCare#497 | 40 | Not disclosed | Not disclosed | 13 states | Alternatives | Visit |