Synergy Rx review
A nationwide platform with round-the-clock support that prints a starting figure on every product card and never says what it commits you to.
- Scores never bought
- 41 providers tracked
- Every factor auditable
- Updated February 2026
Synergy Rx scores where it does because of what it will not tell you.
- Semaglutide
- $199/mo (starting at, terms undisclosed)
- Tirzepatide
- $349/mo (starting at, terms undisclosed)
- Coverage
- All 50 states
- Brand-name
- Compounded only
- Oral option
- Yes
- Verification
- LegitScript-certified
Best for: People who value 24/7 access to a care team and want to see a number before starting an intake, even an incomplete one.
MatchScript's take: Publishes prices for its longevity injections and none at all for the GLP-1 it is listed here for.
The factor breakdown
Synergy Rx on the six Match Score factors — the same sub-scores the quiz reweights to your priorities. See the methodology.
There is no GLP-1 price to score. A provider that publishes nothing you can compare before an intake cannot be credited with value it has not demonstrated, so Budget Fit is 60.
Confirmed all-50-state access means it can usually prescribe within days, for a strong 88 on Speed to Start.
Synergy Rx adds an oral/sublingual route on top of injectables, for a below-par 70 on Formulary Match.
Support lands at a middling 78 — lighter, meds-first support.
Flexibility scores a below-par 70 — fewer levers to flex your plan.
No GLP-1 price on the public site, no published state list, and mandatory arbitration with a class-action waiver give a 58 — the lowest Transparency score on this board.
Pricing in context
How Synergy Rx's monthly price sits against the category median and the cheapest provider we track.
What we like
- Available in all 50 states, subject to state telehealth rules
- Unlimited 24/7 access to a care team, with unlimited appointments and messaging included
- LegitScript-certified, running on a named clinician network with four named 503A pharmacies
- Prices its longevity catalogue openly, so the opacity is specific to weight loss rather than universal
The caveats
- Publishes no GLP-1 price anywhere on its public site — you cannot compare it on cost before committing to an intake
- Its full active-state list is not published; you have to contact support for it
- Mandatory individual arbitration with a class-action waiver, non-refundable consultation fees, and all prescription sales final
- Shares a clinician network and pharmacies with Breeze Meds and Care Bare Rx, and its correct domain is synergyrx.co — synergyrx.com is an unrelated parked domain
Who it's for — and who should skip it
Choose Synergy Rx if people who value 24/7 access to a care team and want to see a number before starting an intake, even an incomplete one.
Skip it if that doesn't sound like you. A closer fit may be System Labs (Match Score 76) — or take the quiz to see where Synergy Rx lands for your priorities.
How it compares to CoreAge Rx & the closest scorer
Synergy Rx against our #1 overall pick and the provider that scores closest to it. Green marks the row leader.
| How it compares | Synergy Rxthis provider | CoreAge Rxour #1 | System Labsclosest scorer |
|---|---|---|---|
| Sema price | $199/mo (starting at, terms undisclosed) | $149/mo | Not disclosed |
| Coverage | All 50 states | All 50 states | Not disclosed |
| Formulary | Injectable + oral | Injectable | Injectable |
| Match Score | 70 · C | 91 · A− | 76 · C |
Synergy Rx, answered
Is Synergy Rx legit?
Yes — Synergy Rx is LegitScript-certified, a third-party check that a telehealth pharmacy operates within the rules. Like most programs here it dispenses compounded GLP-1s, which are made by a licensed pharmacy but aren't FDA-approved; confirm your prescriber is US-licensed at intake.
How much does Synergy Rx cost?
Synergy Rx lists compounded semaglutide from $199/mo (starting at, terms undisclosed) and tirzepatide from $349/mo (starting at, terms undisclosed) — right at our category median. These are the provider's public figures at our last review (February 2026); confirm on their site, since some teaser tiers step up after month one.
Does Synergy Rx ship to my state?
Yes — Synergy Rx reports availability in all 50 states, so most people can start within days.
Synergy Rx vs CoreAge Rx — which is better?
Both are on our board. Synergy Rx scores 70/100; CoreAge Rx leads our default ranking at 91/100 for its flat nationwide pricing on both molecules and easy cancellation. Synergy Rx can still win for you if its strengths match your priorities — best for: People who value 24/7 access to a care team and want to see a number before starting an intake, even an incomplete one. Run the quiz to see which comes out ahead for you.
Pricing & state data last verified February 2026 from Synergy Rx's public site and our master provider matrix. The Match Score and its sub-scores are our editorial judgment per the methodology. Commercial facts only — prices change, so confirm on Synergy Rx's site. Not medical advice; see our disclosure.
Synergy Rx scores where it does because of what it will not tell you. It reaches all 50 states, includes unlimited 24/7 access to a care team, is LegitScript-certified, and runs on a named clinician network with four named 503A pharmacies — and it prices its longevity catalogue openly, so the opacity is specific to weight loss rather than universal. But it publishes no GLP-1 price anywhere on its public site: the Weight Loss category renders no priced products at all, and the cost FAQ says only that pricing varies by treatment plan and medication. Its full active-state list requires contacting support, consultation fees are non-refundable, all prescription sales are final, and disputes go to individual arbitration with a class-action waiver. It also shares a clinician network with Breeze Meds and Care Bare Rx. If you cannot compare it on cost before committing to an intake, we cannot rank it as though you could.
Compare with other providers
Our next-best picks in default ranking order — or open the full list of all 40.
- #1Match91/ 100CoreAge RxThe best all-around match: nationwide access, both molecules at one flat, no-surprise price, and an easy exit.91/100
- #2Match88/ 100Strut HealthThe only program here carrying both LegitScript and ACHC accreditation, with an oral lozenge route on both molecules at the cheapest entry on this board.88/100
- #3Match86/ 100HealthRXA LegitScript-certified, physician-supervised program with a rare oral GLP-1 tablet alongside injectables — both molecules, transparent no-insurance pricing, and a brand-name path.86/100
- #4Match86/ 100ShedRxA weight-focused program that also offers an oral/sublingual route for the needle-averse.86/100
- #5Match88/ 100Ondra HealthNear rock-bottom pricing on both molecules plus some brand access — a rare budget-and-breadth combo, nationwide.88/100
See all 40 providersHide full list
| Provider | Tirzepatide price | Coverage | Alternatives | Go | ||
|---|---|---|---|---|---|---|
| CoreAge Rx#1 | 91 | $149/mo | $349/mo | All 50 states | Alternatives | Visit |
| Strut Health#2 | 88 | $99/mo auto-refill | $199/mo auto-refill | 49 states — list not disclosed | Alternatives | Visit |
| HealthRX#3 | 86 | $189/mo | $349/mo | All 50 states | Alternatives | Visit |
| ShedRx#4 | 86 | $199/mo | $299/mo | All 50 states | Alternatives | Visit |
| Ondra Health#5 | 88 | $93/mo | $166/mo | All 50 states | Alternatives | Visit |
| Enhance MD#6 | 85 | $212/mo | $280/mo | 39 states | Alternatives | Visit |
| Eden#7 | 87 | $239/mo | $349/mo | All 50 states | Alternatives | Visit |
| Vaylen#8 | 87 | $179/mo | $239/mo | All 50 states | Alternatives | Visit |
| Found#9 | 84 | $289/mo month-to-month cash | $289/mo month-to-month cash | All 50 states | Alternatives | Visit |
| yourEra#10 | 84 | $199/mo | $299/mo | All 50 states | Alternatives | Visit |
| Telos Rx#11 | 84 | $49/mo | $99/mo | All 50 states | Alternatives | Visit |
| Trimi#12 | 84 | $129/mo | $229/mo | All 50 states | Alternatives | Visit |
| Sprout Health#13 | 84 | $149/mo starting | $199/mo starting | 44 states — list not disclosed | Alternatives | Visit |
| Alan Meds#14 | 86 | $99/mo | $145/mo | All 50 states | Alternatives | Visit |
| Curex#15 | 86 | $199/mo | $199/mo | All 50 states | Alternatives | Visit |
| Effecty#16 | 86 | $160/mo | $240/mo | All 50 states | Alternatives | Visit |
| Breeze Meds#17 | 83 | $199/mo starting | $399/mo starting | All 50 states | Alternatives | Visit |
| Invigor Medical#18 | 85 | $199/mo | $339/mo | All 50 states | Alternatives | Visit |
| Ro#19 | 85 | Not disclosed | Not disclosed | All 50 states | Alternatives | Visit |
| RxSpan MD#20 | 85 | $249/mo | $329/mo | All 50 states | Alternatives | Visit |
| Tyde Wellness#21 | 85 | $149/mo | $249/mo | All 50 states | Alternatives | Visit |
| Direct Meds#22 | 82 | $179/mo | $224/mo | All 50 states | Alternatives | Visit |
| Oak#23 | 82 | $119/mo flat at every dose | $185/mo flat at every dose | 45 states — full list not disclosed | Alternatives | Visit |
| Care Bare Rx#24 | 82 | Not disclosed | Not disclosed | All 50 states | Alternatives | Visit |
| BetterMe Rx#25 | 84 | $199/mo | $299/mo | All 50 states | Alternatives | Visit |
| Fitish#26 | 84 | $219/mo | $339/mo | All 50 states | Alternatives | Visit |
| Sesame Care#27 | 81 | Not disclosed | Not disclosed | Not disclosed | Alternatives | Visit |
| AgelessRx#28 | 83 | $139/mo | Not disclosed | All 50 states | Alternatives | Visit |
| Hims & Hers#29 | 83 | $199/mo | Not disclosed | All 50 states | Alternatives | Visit |
| REMEVi#30 | 83 | $199/mo | $269/mo | All 50 states | Alternatives | Visit |
| Gala Health#31 | 80 | Not disclosed | $179/mo (yearly subscription) | All 50 states | Alternatives | Visit |
| Henry Meds#32 | 82 | $249/mo | $349/mo | All 50 states | Alternatives | Visit |
| Mochi Health#33 | 82 | $138/mo | $238/mo | AZ, CO, FL, GA, IL, MA, MD, MN, NY, OR, PA, RI, TX, VA, WA | Alternatives | Visit |
| Direct GLP#34 | 82 | $65/mo | $110/mo | WA, NM, AZ, UT, FL, DC, KS, OK, VA, GA | Alternatives | Visit |
| MadeMed#35 | 79 | $219/mo billed quarterly | $399/mo billed quarterly | Not disclosed | Alternatives | Visit |
| Fella Health#36 | 81 | $165/mo | $399/mo | CA, TX, FL, NY, WA, AZ, IL, MI, MN, MO, NC, OH, PA, WI, NJ, MA, CO, IN, VA, GA | Alternatives | Visit |
| Optimized Health#37 | 81 | $200/mo | $250/mo | MO, IA, KS, UT, WA | Alternatives | Visit |
| Wellorithm#38 | 77 | $247/mo standing | $349/mo standing | 49 states — Louisiana excluded | Alternatives | Visit |
| System Labs#39 | 76 | Not disclosed | $179/mo standing | Not disclosed | Alternatives | Visit |
| Gaya Wellness#40 | 77 | $349/mo | $349/mo | FL, NC, VA, IN, TN | Alternatives | Visit |